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	<title>Comments on: The Mathematics of NT-plus Screening</title>
	<atom:link href="http://www.stubbornmule.net/2008/09/bayes-formula/feed/" rel="self" type="application/rss+xml" />
	<link>http://www.stubbornmule.net/2008/09/bayes-formula/</link>
	<description>Obstinately objective</description>
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		<title>By: stubbornmule</title>
		<link>http://www.stubbornmule.net/2008/09/bayes-formula/comment-page-1/#comment-1645</link>
		<dc:creator>stubbornmule</dc:creator>
		<pubDate>Tue, 30 Sep 2008 13:49:15 +0000</pubDate>
		<guid isPermaLink="false">http://www.stubbornmule.net/?p=1272#comment-1645</guid>
		<description>@Mark: thanks, what you suggest here does make sense. I will have a bit more of a think about it to see how to to take this into account.</description>
		<content:encoded><![CDATA[<p>@Mark: thanks, what you suggest here does make sense. I will have a bit more of a think about it to see how to to take this into account.</p>
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		<title>By: Mark L</title>
		<link>http://www.stubbornmule.net/2008/09/bayes-formula/comment-page-1/#comment-1639</link>
		<dc:creator>Mark L</dc:creator>
		<pubDate>Tue, 30 Sep 2008 08:02:55 +0000</pubDate>
		<guid isPermaLink="false">http://www.stubbornmule.net/?p=1272#comment-1639</guid>
		<description>Hi Sean,

I don&#039;t have time to think about this deeply right now, but perhaps you could check
my reasoning and let me know what you think.  

The problem with your argument lies in your explanation of cut-off risk being &quot;the 
chance of having Down Syndrome given a high risk result&quot;.  My interpretation of 
cut-off risk would be something more like the lowest chance of having down syndrome 
amongst all cases who receive a high risk result (or equivalently, the highest chance
of having down syndrome amongst cases who receive a low risk result).  Perhaps 
you could call this the marginal probability density at the cut-off.  The value you are 
calculating is not the cut-off, but rather the average probability density over all cases 
with a high risk result, that is, all cases with conditional probability above the cut-off.  

Naturally, the cut-off probability must be (substantially) less than the average 
amongst cases above that cut-off, which is what you observe in the figures.
Does that make sense?

Cheers,
Mark</description>
		<content:encoded><![CDATA[<p>Hi Sean,</p>
<p>I don&#8217;t have time to think about this deeply right now, but perhaps you could check<br />
my reasoning and let me know what you think.  </p>
<p>The problem with your argument lies in your explanation of cut-off risk being &#8220;the<br />
chance of having Down Syndrome given a high risk result&#8221;.  My interpretation of<br />
cut-off risk would be something more like the lowest chance of having down syndrome<br />
amongst all cases who receive a high risk result (or equivalently, the highest chance<br />
of having down syndrome amongst cases who receive a low risk result).  Perhaps<br />
you could call this the marginal probability density at the cut-off.  The value you are<br />
calculating is not the cut-off, but rather the average probability density over all cases<br />
with a high risk result, that is, all cases with conditional probability above the cut-off.  </p>
<p>Naturally, the cut-off probability must be (substantially) less than the average<br />
amongst cases above that cut-off, which is what you observe in the figures.<br />
Does that make sense?</p>
<p>Cheers,<br />
Mark</p>
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	</item>
	<item>
		<title>By: stubbornmule</title>
		<link>http://www.stubbornmule.net/2008/09/bayes-formula/comment-page-1/#comment-1628</link>
		<dc:creator>stubbornmule</dc:creator>
		<pubDate>Tue, 30 Sep 2008 01:04:18 +0000</pubDate>
		<guid isPermaLink="false">http://www.stubbornmule.net/?p=1272#comment-1628</guid>
		<description>@BInSains: number three is on the way.</description>
		<content:encoded><![CDATA[<p>@BInSains: number three is on the way.</p>
]]></content:encoded>
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	<item>
		<title>By: BInSains</title>
		<link>http://www.stubbornmule.net/2008/09/bayes-formula/comment-page-1/#comment-1621</link>
		<dc:creator>BInSains</dc:creator>
		<pubDate>Mon, 29 Sep 2008 13:14:32 +0000</pubDate>
		<guid isPermaLink="false">http://www.stubbornmule.net/?p=1272#comment-1621</guid>
		<description>Which leads to another question...  Why are you looking at NT Screening Sean?

Is there something we should know?</description>
		<content:encoded><![CDATA[<p>Which leads to another question&#8230;  Why are you looking at NT Screening Sean?</p>
<p>Is there something we should know?</p>
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		<title>By: Kwoff.com</title>
		<link>http://www.stubbornmule.net/2008/09/bayes-formula/comment-page-1/#comment-1619</link>
		<dc:creator>Kwoff.com</dc:creator>
		<pubDate>Mon, 29 Sep 2008 06:35:55 +0000</pubDate>
		<guid isPermaLink="false">http://www.stubbornmule.net/?p=1272#comment-1619</guid>
		<description>&lt;strong&gt;The Mathematics of NT-plus Screening &#124; A Stubborn Mule&#039;s Perspective...&lt;/strong&gt;

Have the clinics got something wrong in the stats for nuchal translucency screening tests?...</description>
		<content:encoded><![CDATA[<p><strong>The Mathematics of NT-plus Screening | A Stubborn Mule&#8217;s Perspective&#8230;</strong></p>
<p>Have the clinics got something wrong in the stats for nuchal translucency screening tests?&#8230;</p>
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